The final week of full-roster football is here before bye weeks kick in, and the Week 4 NFL odds are serving major heat. We’re getting the league’s first London game with the Colts favored by 3.5 over the Commanders, plus a juicy 20th-anniversary "Domecoming" rematch between the Saints and Falcons on Monday night.
The model's hot takes
If you're hunting for the best bets, SportsLine’s advanced computer model—which has crushed it with a 54-43 run on top-rated picks since 2024—has crunched the data across 10,000 simulations.
One of the model’s top locks? The Giants (+2.5) covering against the Cardinals. The Cards have been struggling, giving up over 31 points in consecutive losses, while the Giants are playing smart, efficient football. The model says New York covers over 50% of the time, and the Over on 44.5 is also looking real good, hitting in 56% of simulations.
Seattle's bounce back
The model is also feeling the Seahawks (-7) to cover against the Chargers. Seattle is looking to avenge a snapped 12-game winning streak and they’re back at home in the PNW, where they haven’t lost in an entire calendar year. Meanwhile, the Chargers are on a six-game skid and really struggling to put points on the board. The model has Seattle covering nearly 60% of the time.
Why it matters
With five different teams projected to win by double digits, there’s a massive opportunity to use alternate lines to secure a bag. This is the last chance for a 16-game betting slate for a while, and the stats suggest the model’s picks are worth the hype.
